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Welcome To The Hockemeyer Lab
The focus of our work is to establish reliable models of human diseases using genetically engineered human and stem cell and mouse models and functional genomics screening approaches. We are particularly interested in developing rigorous genetic approaches to study human disease, development and cell biology where conventional animal models or tissue culture systems do not adequately recapitulate human biology. To do this we are leveraging our expertise in human stem cell techniques and genome editing, humanized mouse models to elucidate processes of human stem cells renewal and differentiation and during tumor formation.
Recent Publications
Stuart A, Zhang B, Hockemeyer D, de Lange T
How telomere attrition protects against cancer.
Nat Rev Genet.
2026 Sep 1.
doi: 10.1038/s41576-026-01001-w. PubMed PMID: 42680848.
Busquets O, Li H, Syed KM, Alvarez Jerez P, Dunnack J, Lo Bu R, Verma Y, Pangilinan GR, Martin A, Straub J, Du Y, Simon VM, Poser S, Bush Z, Diaz J, Sahagun A, Gao J, Hong S, Hernandez DG, Levine KS, Pochet N, Booth EO, Blanchette M, Bateup HS, Rio DC, Blauwendraat C, Hockemeyer D, Soldner F
iSCORE-PD: an isogenic stem cell collection to research Parkinson's disease.
Nat Commun
2026 Jun 17;17(1):7682.
doi: 10.1038/s41467-026-74355-8. PubMed PMID: 42310027; PubMed Central PMCID: PMC13434110.
Horacek AG, Kueper FL, Lu R, Lamont IP, Tran S, Li H, Hockemeyer D
Decoding the BRCA2 reversion principles underlying PARP inhibitor resistance.
bioRxiv [Preprint]
2026 May 10.
doi: 10.64898/2026.04.29.721733. PubMed PMID: 42146705; PubMed Central PMCID: PMC13174588.
Martin A, Hockemeyer D.
Regulation of Human Telomerase: From Molecular Interactions to Population Genetics
Cold Spring Harb Perspect Biol.
2026 May 1.
doi: 10.1101/cshperspect.a041693. PubMed PMID: 40389313.
Martin M, Lu R, Blake A, Nichols KE, Sanchez SE, Artrandi SE, Sharma R, Hockemeyer D.
Telomere length of both parents contribute to heritable POT1 cancer-predisposition syndrome.
bioRxiv
2026 Feb 11.
doi: 10.64898/2026.02.09.704652. PubMed PMID: 41727162; PubMed Central PMCID: PMC12918948.
Recent News
2023 Hockemeyer Holiday Party
12/2023
2022 Hockemeyer Holiday Party
12/2022
2022 Hockemeyer Halloween Party
10/2022
